2007

Campbell, P.M., Groehler, A.L., Lee, K.M., Ouellette, M.M., Khazak, V. and Der, C.J. (2007).  K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling.  Cancer Res, 67, 2098-2106.

Shields, J.M., Thomas, N.E., Cregger, M., Berger, A.J., Leslie, M., Torrice, C., Hao, H., Penland, S., Arbiser, J., Scott, G., Zhou, T., Bar-Eli, M., Bear, J.E., Der, C.J., Kaufmann, W., Rimm, D.L. and Sharpless, N.E.  (2007). Lack of ERK mitogen-activated protein kinase activation and signaling demonstrates a new type of melanoma.  Cancer Res, 67, 1502-1512.

Hao, H., Muniz-Medina, V.M., Mehta, H., Thomas, N.E., Klazak, V., Der, C.J. and Shields, J.M.  (2007). Differential roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth.  Mol. Cancer Res., 6, 2220-2229.

Repasky, G.A., Zhou, Y., Morita, S. and Der, C.J. (2007). Ras activation of Raf-dependent and Raf-independent signaling causes cyclooxygenase-2-mediated prostaglandin E2 signaling required for intestinal epithelial cell transformation.  Mol Carcinogenesis, 46,958-970.

Shutes, A., Onesto, C., Picard, V., Schweighoffer, F. and Der, C.J.  (2007). Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. J. Biol. Chem., 282, 35666-35678.

Yohe, M.E., Rossman, K.L., Gardner, O.S., Karnoub, A.E., Snyder, J.T., Gershburg, S., Graves, L.M., Der, C.J. and Sondek, J. (2007). Auto-inhibition of the Dbl-family protein Tim by an N-terminal helical motif.  J. Biol. Chem., 282, 13813-13823.

Mitin, N., Betts, L., Yohe, M., Sondek, J., Der, C.J. and Rossman, K.L.  Release of auto-inhibition of Asef by APC leads to Cdc42 activation and tumor suppression.  (2007). Nature Struct. Mol. Biol., 14, 814-823.

Falsetti, S.C., Wang, D.A., Peng, H., Carrico, D., Cox, A.D., Der, C.J., Hamilton, A.D., Sebti, S.M. (2007). Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. Mol. Cell. Biol. 27, 8003-8014.

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